| PML |
PML-RARA |
FUS |
Acute Promyelocytic Leukemia |
Tretinoin |
I |
1 |
|
Evidence region
CGI
Patient Criteria
-
Note
-
Gene name
PML
Full name
PML nuclear body scaffold
Gene type
protein-coding
Function
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Drug name
Tretinoin
DrugBank ID
DB00755
Synonyms
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid (ECL)
Acide retinoique
all trans Retinoic acid
all trans-Retinoic acid
all-(E)-Retinoic acid
all-trans-beta-Retinoic acid
all-trans-Retinoic acid
all-trans-Tretinoin
all-trans-Vitamin A acid
all-trans-Vitamin A1 acid
ATRA
beta-Retinoic acid
Retinoic acid
Retionic acid
trans-Retinoic acid
Tretin M
Tretinoin
Tretinoina
Trétinoïne
Tretinoinum
Vitamin A acid
Brand
Hydroquinone 6% / Tretinoin 0.05% / Triamcinolone 0.025%
Retin-A MICRO
Vitamin A Acid
Benzoyl Peroxide 2.5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.025%
Clindamycin Phosphate and Tretinoin
Vitamin A Acid 0.1% Cream
Desoximetasone 0.05% / Hydroquinone 6% / Tretinoin 0.05%
Benzoyl Peroxide 5% / Niacinamide 2% / Tretinoin 0.025%
TRETIN-X Gel 0.01%
Tri-luma
TRETIN-X Cream 0.1%
Minoxidil 7% / Progesterone 0.1% / Tretinoin 0.025%
Hydroquinone 4% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.025%
Hydroquinone 4% / Tretinoin 0.025%
Niacinamide 2% / Spironolactone 5% / Tretinoin 0.025%
Vitamin A Acid 0.01% Cream
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.1%
141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Hydroquinone 5% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%
Solagé
011021 Niacinamide 4% / Tretinoin 0.05%
Dermawerx Zmt Pak
Refissa
Stievamycin Regular
Imiquimod 5% / Tretinoin 0.025%
Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Retin-A
011013 Niacinamide 4% / Tretinoin 0.025%
011218 Niacinamide 2% / Spironolactone 5% / Tretinoin 0.025%
141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%
Tretinoin (Emollient)
Tretinoin Gel Microsphere
Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%
Avita
Vitamin A Acid 0.025% Cream
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.1%
Stieva-A Gel
Hydroquinone 6% /tretinoin 0.05%
Obagi
Vitinoin - Crm 0.05%
011020 Niacinamide 4% / Tretinoin 0.05%
Benzoyl Peroxide 5% / Clindamycin1% / Niacinamide 2% / Tretinoin 0.025%
Clindamycin 1% / Sodium Sulfacetamide Monohydrate 5% / Tretinoin 0.025%
Tretinoin Cream
Benzoyl Peroxide 2.5%, Clindamycin Phosphate 1%, Niacinamide 2% / Tretinoin 0.05%
Clindamycin Phosphate and Tretinion
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.05%
Tretinoin
Biacna Topical Gel
TretinX
Imiquimod 5% / Salicylic Acid 30% / Tretinoin 0.1%
TRETIN-X Cream 0.05%
Ascorbyl Palmitate 2% / Hyaluronic Acid Sodium Salt 0.2% / Niacinamide 5% / Tretinoin 0.025%
Tretin-X
Vitinoin - Crm 0.025%
Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05%
Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05%
OLIVIA QUIDO FIRM and FADE I
Rejuva-A
Hydroquinone 8% / Tretinoin 0.025%.
011220 Niacinamide 2% / Spironolactone 5% / Tretinoin 0.05%
Vitinoin Gel - 0.025%
Dexamethasone Sodium Phosphate 0.1% / Finasteride 0.1% / Minoxidil 5% / Tretinoin 0.025%
Tretinopak
Fluocinolone Acetonide 0.01% / Minoxidil 5% / Tretinoin 0.025%
Clindamycin 1% / Niacinamide 4% / Spironolactone 2% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.05%
Hydroquinone 8% / Tretinoin 0.025%
Dermapak Plus
OLIVIA QUIDO FIRM and FADE II
Stievamycin Mild
Vitamin A Acid 0.05% Cream
Niacinamide 4% / Tretinoin 0.1%
Hyaluronic Acid Sodium Salt 0.5% / Hydroquinone 4% / Tretinoin 0.05%
Renova
Minoxidil 5% / Progesterone 0.1% / Tretinoin 0.025%
011010 Niacinamide 4% / Tretinoin 0.025%
Veltin
TRETIN-X Cream 0.025%
Niacinamide 4% / Tretinoin 0.025%
Finasteride 0.1% / Minoxidil 7% / Tretinoin 0.025%
Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Tretinoin 0.05%
Solage
Dapsone 8.5% / Niacinamide 2% / Tretinoin 0.025%
Stievaa Gel 0.01%
Stievamycin Forte
Tretinoin Gel
Vitinoin - Crm 0.1%
141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.05%
Clindamycin 1% / Niacinamide 4% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.025%
Dr. Throwers Pbc No. 1
Retisol-A
Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05%
Clindamycin 1% / Niacinamide 4% / Tretinoin 0.05%
Minoxidil 7% / Tretinoin 0.025%
Dapsone 6% / Niacinamide 2% / Tretinoin 0.025%
Stieva-A Cream
Vesanoid
Ziana
Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%
Niacinamide 2% / Spironolactone 5% / Tretinoin 0.05%
Dr. Throwers Hydrotet
141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Tretin.x
Refissa Tretinoin (Emollient)
Stie Vaa Sol 0.05%
Cenovia
TRETIN-X Gel 0.025%
Altreno
Clindamycin Phosphate 1.2% and Tretinoin 0.025%
Niacinamide 4% / Tretinoin 0.05%
Stieva-A Solution
Atralin
Description
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Target gene| Gene | Function |
|---|
| RXRB | agonist | | RXRG | agonist | | RARG | agonist | | ALDH1A1 | Unknown | | GPRC5A | Unknown | | ALDH1A2 | Unknown | | RARRES1 | agonist | | RARA | Unknown | | RARB | Unknown | | LCN1 | Unknown | | OBP2A | Unknown | | RBP4 | Unknown | | PDK4 | Unknown | | RXRA | Unknown | | CYP26A1 | Unknown | | CYP26B1 | Unknown | | CYP26C1 | Unknown | | HPGDS | Unknown |
|
| PML |
PML-RARA |
FUS |
Acute Promyelocytic Leukemia |
Arsenic trioxide |
RII |
1 |
|
Evidence region
CIVIC
Patient Criteria
A216V
Note
Five point mutations were identified in the PML B2 domain of PML-RARA transcripts in 9 patients diagnosed with APL and resistant to arsenic. DNA from these 9 patients was cloned into flag-tagged pCag expression vectors. Immunoblotting analyses demonstrated that after the addition of arsenic, the A216V, S214L, and A216T mutants experienced no change in expression or degradation when compared to wild type cells, indicating that these mutants were not inhibited by arsenic and demonstrate resistance. Immunofluorescent measurements indicated arsenic treatment did not alter the nuclear localization pattern of mutants A216V, S214L, or A216T, but had an effect on the localization of other mutants as well as wild type cells.
Gene name
PML
Full name
PML nuclear body scaffold
Gene type
protein-coding
Function
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Drug name
Arsenic trioxide
DrugBank ID
DB01169
Synonyms
Acide Arsenieux
Anhydride Arsenieux
Arsenic Blanc
Arsenic oxide
Arsenic trioxide
Arsenic(III) oxide
arsénico trióxido
Arsenigen Saure
Arsenolite
Arsenous oxide
Arsenous oxide anhydride
Diarsenic oxide
Diarsenic trioxide
White arsenic
Brand
Arsenic trioxide
Arsenic Trioxide Accord
Arsenic Trioxide for Injection
Arsenic Trioxide Mylan Infusion
Teva-arsenic Trioxide for Injection
Arsenic Trioxide Mylan
Arsenic Trioxide
Trisenox
Arsenic Trioxide Solution for Injection
Arsenic Trioxide Medac
Description
Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.
Target gene| Gene | Function |
|---|
| IKBKB | inducer | | TXNRD1 | inhibitor | | JUN | inducer | | CCND1 | antagonist | | MAPK3 | inducer | | MAPK1 | inducer | | AKT1 | inducer | | CDKN1A | Unknown | | HDAC1 | Unknown | | PML | Unknown |
|
| PML |
PML-RARA |
FUS |
Acute Promyelocytic Leukemia |
Arsenic trioxide+Tretinoin |
I |
1 |
|
Evidence region
CIVIC
Patient Criteria
-
Note
ATRA/Arsenic combined with standard chemotherapy has been shown to induce a complete remission rate of greater than 75% of patients with acute promyelocytic leukemia harboring the PML-RARa fusion.
Gene name
PML
Full name
PML nuclear body scaffold
Gene type
protein-coding
Function
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Drug name
Arsenic trioxide
DrugBank ID
DB01169
Synonyms
Acide Arsenieux
Anhydride Arsenieux
Arsenic Blanc
Arsenic oxide
Arsenic trioxide
Arsenic(III) oxide
arsénico trióxido
Arsenigen Saure
Arsenolite
Arsenous oxide
Arsenous oxide anhydride
Diarsenic oxide
Diarsenic trioxide
White arsenic
Brand
Arsenic trioxide
Arsenic Trioxide Accord
Arsenic Trioxide for Injection
Arsenic Trioxide Mylan Infusion
Teva-arsenic Trioxide for Injection
Arsenic Trioxide Mylan
Arsenic Trioxide
Trisenox
Arsenic Trioxide Solution for Injection
Arsenic Trioxide Medac
Description
Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.
Target gene| Gene | Function |
|---|
| IKBKB | inducer | | TXNRD1 | inhibitor | | JUN | inducer | | CCND1 | antagonist | | MAPK3 | inducer | | MAPK1 | inducer | | AKT1 | inducer | | CDKN1A | Unknown | | HDAC1 | Unknown | | PML | Unknown |
Drug name
Tretinoin
DrugBank ID
DB00755
Synonyms
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid (ECL)
Acide retinoique
all trans Retinoic acid
all trans-Retinoic acid
all-(E)-Retinoic acid
all-trans-beta-Retinoic acid
all-trans-Retinoic acid
all-trans-Tretinoin
all-trans-Vitamin A acid
all-trans-Vitamin A1 acid
ATRA
beta-Retinoic acid
Retinoic acid
Retionic acid
trans-Retinoic acid
Tretin M
Tretinoin
Tretinoina
Trétinoïne
Tretinoinum
Vitamin A acid
Brand
Hydroquinone 6% / Tretinoin 0.05% / Triamcinolone 0.025%
Retin-A MICRO
Vitamin A Acid
Benzoyl Peroxide 2.5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.025%
Clindamycin Phosphate and Tretinoin
Vitamin A Acid 0.1% Cream
Desoximetasone 0.05% / Hydroquinone 6% / Tretinoin 0.05%
Benzoyl Peroxide 5% / Niacinamide 2% / Tretinoin 0.025%
TRETIN-X Gel 0.01%
Tri-luma
TRETIN-X Cream 0.1%
Minoxidil 7% / Progesterone 0.1% / Tretinoin 0.025%
Hydroquinone 4% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.025%
Hydroquinone 4% / Tretinoin 0.025%
Niacinamide 2% / Spironolactone 5% / Tretinoin 0.025%
Vitamin A Acid 0.01% Cream
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.1%
141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Hydroquinone 5% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%
Solagé
011021 Niacinamide 4% / Tretinoin 0.05%
Dermawerx Zmt Pak
Refissa
Stievamycin Regular
Imiquimod 5% / Tretinoin 0.025%
Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Retin-A
011013 Niacinamide 4% / Tretinoin 0.025%
011218 Niacinamide 2% / Spironolactone 5% / Tretinoin 0.025%
141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%
Tretinoin (Emollient)
Tretinoin Gel Microsphere
Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%
Avita
Vitamin A Acid 0.025% Cream
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.1%
Stieva-A Gel
Hydroquinone 6% /tretinoin 0.05%
Obagi
Vitinoin - Crm 0.05%
011020 Niacinamide 4% / Tretinoin 0.05%
Benzoyl Peroxide 5% / Clindamycin1% / Niacinamide 2% / Tretinoin 0.025%
Clindamycin 1% / Sodium Sulfacetamide Monohydrate 5% / Tretinoin 0.025%
Tretinoin Cream
Benzoyl Peroxide 2.5%, Clindamycin Phosphate 1%, Niacinamide 2% / Tretinoin 0.05%
Clindamycin Phosphate and Tretinion
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.05%
Tretinoin
Biacna Topical Gel
TretinX
Imiquimod 5% / Salicylic Acid 30% / Tretinoin 0.1%
TRETIN-X Cream 0.05%
Ascorbyl Palmitate 2% / Hyaluronic Acid Sodium Salt 0.2% / Niacinamide 5% / Tretinoin 0.025%
Tretin-X
Vitinoin - Crm 0.025%
Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05%
Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05%
OLIVIA QUIDO FIRM and FADE I
Rejuva-A
Hydroquinone 8% / Tretinoin 0.025%.
011220 Niacinamide 2% / Spironolactone 5% / Tretinoin 0.05%
Vitinoin Gel - 0.025%
Dexamethasone Sodium Phosphate 0.1% / Finasteride 0.1% / Minoxidil 5% / Tretinoin 0.025%
Tretinopak
Fluocinolone Acetonide 0.01% / Minoxidil 5% / Tretinoin 0.025%
Clindamycin 1% / Niacinamide 4% / Spironolactone 2% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.05%
Hydroquinone 8% / Tretinoin 0.025%
Dermapak Plus
OLIVIA QUIDO FIRM and FADE II
Stievamycin Mild
Vitamin A Acid 0.05% Cream
Niacinamide 4% / Tretinoin 0.1%
Hyaluronic Acid Sodium Salt 0.5% / Hydroquinone 4% / Tretinoin 0.05%
Renova
Minoxidil 5% / Progesterone 0.1% / Tretinoin 0.025%
011010 Niacinamide 4% / Tretinoin 0.025%
Veltin
TRETIN-X Cream 0.025%
Niacinamide 4% / Tretinoin 0.025%
Finasteride 0.1% / Minoxidil 7% / Tretinoin 0.025%
Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Tretinoin 0.05%
Solage
Dapsone 8.5% / Niacinamide 2% / Tretinoin 0.025%
Stievaa Gel 0.01%
Stievamycin Forte
Tretinoin Gel
Vitinoin - Crm 0.1%
141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.05%
Clindamycin 1% / Niacinamide 4% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.025%
Dr. Throwers Pbc No. 1
Retisol-A
Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05%
Clindamycin 1% / Niacinamide 4% / Tretinoin 0.05%
Minoxidil 7% / Tretinoin 0.025%
Dapsone 6% / Niacinamide 2% / Tretinoin 0.025%
Stieva-A Cream
Vesanoid
Ziana
Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%
Niacinamide 2% / Spironolactone 5% / Tretinoin 0.05%
Dr. Throwers Hydrotet
141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Tretin.x
Refissa Tretinoin (Emollient)
Stie Vaa Sol 0.05%
Cenovia
TRETIN-X Gel 0.025%
Altreno
Clindamycin Phosphate 1.2% and Tretinoin 0.025%
Niacinamide 4% / Tretinoin 0.05%
Stieva-A Solution
Atralin
Description
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Target gene| Gene | Function |
|---|
| RXRB | agonist | | RXRG | agonist | | RARG | agonist | | ALDH1A1 | Unknown | | GPRC5A | Unknown | | ALDH1A2 | Unknown | | RARRES1 | agonist | | RARA | Unknown | | RARB | Unknown | | LCN1 | Unknown | | OBP2A | Unknown | | RBP4 | Unknown | | PDK4 | Unknown | | RXRA | Unknown | | CYP26A1 | Unknown | | CYP26B1 | Unknown | | CYP26C1 | Unknown | | HPGDS | Unknown |
|
| PML |
PML-RARA |
FUS |
Acute Promyelocytic Leukemia |
Tretinoin |
II |
1 |
|
Evidence region
CIVIC
Patient Criteria
-
Note
Fusion protein degradation is accelerated upon ATRA treatment of acute promyelocytic cells at pharmalogical concentrations.
Gene name
PML
Full name
PML nuclear body scaffold
Gene type
protein-coding
Function
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Drug name
Tretinoin
DrugBank ID
DB00755
Synonyms
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid (ECL)
Acide retinoique
all trans Retinoic acid
all trans-Retinoic acid
all-(E)-Retinoic acid
all-trans-beta-Retinoic acid
all-trans-Retinoic acid
all-trans-Tretinoin
all-trans-Vitamin A acid
all-trans-Vitamin A1 acid
ATRA
beta-Retinoic acid
Retinoic acid
Retionic acid
trans-Retinoic acid
Tretin M
Tretinoin
Tretinoina
Trétinoïne
Tretinoinum
Vitamin A acid
Brand
Hydroquinone 6% / Tretinoin 0.05% / Triamcinolone 0.025%
Retin-A MICRO
Vitamin A Acid
Benzoyl Peroxide 2.5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.025%
Clindamycin Phosphate and Tretinoin
Vitamin A Acid 0.1% Cream
Desoximetasone 0.05% / Hydroquinone 6% / Tretinoin 0.05%
Benzoyl Peroxide 5% / Niacinamide 2% / Tretinoin 0.025%
TRETIN-X Gel 0.01%
Tri-luma
TRETIN-X Cream 0.1%
Minoxidil 7% / Progesterone 0.1% / Tretinoin 0.025%
Hydroquinone 4% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.025%
Hydroquinone 4% / Tretinoin 0.025%
Niacinamide 2% / Spironolactone 5% / Tretinoin 0.025%
Vitamin A Acid 0.01% Cream
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.1%
141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Hydroquinone 5% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%
Solagé
011021 Niacinamide 4% / Tretinoin 0.05%
Dermawerx Zmt Pak
Refissa
Stievamycin Regular
Imiquimod 5% / Tretinoin 0.025%
Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Retin-A
011013 Niacinamide 4% / Tretinoin 0.025%
011218 Niacinamide 2% / Spironolactone 5% / Tretinoin 0.025%
141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%
Tretinoin (Emollient)
Tretinoin Gel Microsphere
Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%
Avita
Vitamin A Acid 0.025% Cream
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.1%
Stieva-A Gel
Hydroquinone 6% /tretinoin 0.05%
Obagi
Vitinoin - Crm 0.05%
011020 Niacinamide 4% / Tretinoin 0.05%
Benzoyl Peroxide 5% / Clindamycin1% / Niacinamide 2% / Tretinoin 0.025%
Clindamycin 1% / Sodium Sulfacetamide Monohydrate 5% / Tretinoin 0.025%
Tretinoin Cream
Benzoyl Peroxide 2.5%, Clindamycin Phosphate 1%, Niacinamide 2% / Tretinoin 0.05%
Clindamycin Phosphate and Tretinion
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.05%
Tretinoin
Biacna Topical Gel
TretinX
Imiquimod 5% / Salicylic Acid 30% / Tretinoin 0.1%
TRETIN-X Cream 0.05%
Ascorbyl Palmitate 2% / Hyaluronic Acid Sodium Salt 0.2% / Niacinamide 5% / Tretinoin 0.025%
Tretin-X
Vitinoin - Crm 0.025%
Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05%
Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05%
OLIVIA QUIDO FIRM and FADE I
Rejuva-A
Hydroquinone 8% / Tretinoin 0.025%.
011220 Niacinamide 2% / Spironolactone 5% / Tretinoin 0.05%
Vitinoin Gel - 0.025%
Dexamethasone Sodium Phosphate 0.1% / Finasteride 0.1% / Minoxidil 5% / Tretinoin 0.025%
Tretinopak
Fluocinolone Acetonide 0.01% / Minoxidil 5% / Tretinoin 0.025%
Clindamycin 1% / Niacinamide 4% / Spironolactone 2% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.05%
Hydroquinone 8% / Tretinoin 0.025%
Dermapak Plus
OLIVIA QUIDO FIRM and FADE II
Stievamycin Mild
Vitamin A Acid 0.05% Cream
Niacinamide 4% / Tretinoin 0.1%
Hyaluronic Acid Sodium Salt 0.5% / Hydroquinone 4% / Tretinoin 0.05%
Renova
Minoxidil 5% / Progesterone 0.1% / Tretinoin 0.025%
011010 Niacinamide 4% / Tretinoin 0.025%
Veltin
TRETIN-X Cream 0.025%
Niacinamide 4% / Tretinoin 0.025%
Finasteride 0.1% / Minoxidil 7% / Tretinoin 0.025%
Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Tretinoin 0.05%
Solage
Dapsone 8.5% / Niacinamide 2% / Tretinoin 0.025%
Stievaa Gel 0.01%
Stievamycin Forte
Tretinoin Gel
Vitinoin - Crm 0.1%
141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.05%
Clindamycin 1% / Niacinamide 4% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.025%
Dr. Throwers Pbc No. 1
Retisol-A
Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05%
Clindamycin 1% / Niacinamide 4% / Tretinoin 0.05%
Minoxidil 7% / Tretinoin 0.025%
Dapsone 6% / Niacinamide 2% / Tretinoin 0.025%
Stieva-A Cream
Vesanoid
Ziana
Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%
Niacinamide 2% / Spironolactone 5% / Tretinoin 0.05%
Dr. Throwers Hydrotet
141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Tretin.x
Refissa Tretinoin (Emollient)
Stie Vaa Sol 0.05%
Cenovia
TRETIN-X Gel 0.025%
Altreno
Clindamycin Phosphate 1.2% and Tretinoin 0.025%
Niacinamide 4% / Tretinoin 0.05%
Stieva-A Solution
Atralin
Description
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Target gene| Gene | Function |
|---|
| RXRB | agonist | | RXRG | agonist | | RARG | agonist | | ALDH1A1 | Unknown | | GPRC5A | Unknown | | ALDH1A2 | Unknown | | RARRES1 | agonist | | RARA | Unknown | | RARB | Unknown | | LCN1 | Unknown | | OBP2A | Unknown | | RBP4 | Unknown | | PDK4 | Unknown | | RXRA | Unknown | | CYP26A1 | Unknown | | CYP26B1 | Unknown | | CYP26C1 | Unknown | | HPGDS | Unknown |
|
| PML |
PML-RARA |
FUS |
Acute Promyelocytic Leukemia |
Tretinoin |
IV |
1 |
|
Evidence region
CIVIC
Patient Criteria
-
Note
A 39-year old woman who presented with acute myeloid leukemia revealed a complicated genetic profile using conventional metaphase cytogenetics and FISH analysis. Whole genome sequencing elucidated a PML-RARA fusion, which can be successfully treated with ATRA. Uncovering this mutation prevented an unnecessary allogeneic transplant and the patient remained in remission 15 months post-treatment (date of publication).
Gene name
PML
Full name
PML nuclear body scaffold
Gene type
protein-coding
Function
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Drug name
Tretinoin
DrugBank ID
DB00755
Synonyms
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid (ECL)
Acide retinoique
all trans Retinoic acid
all trans-Retinoic acid
all-(E)-Retinoic acid
all-trans-beta-Retinoic acid
all-trans-Retinoic acid
all-trans-Tretinoin
all-trans-Vitamin A acid
all-trans-Vitamin A1 acid
ATRA
beta-Retinoic acid
Retinoic acid
Retionic acid
trans-Retinoic acid
Tretin M
Tretinoin
Tretinoina
Trétinoïne
Tretinoinum
Vitamin A acid
Brand
Hydroquinone 6% / Tretinoin 0.05% / Triamcinolone 0.025%
Retin-A MICRO
Vitamin A Acid
Benzoyl Peroxide 2.5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.025%
Clindamycin Phosphate and Tretinoin
Vitamin A Acid 0.1% Cream
Desoximetasone 0.05% / Hydroquinone 6% / Tretinoin 0.05%
Benzoyl Peroxide 5% / Niacinamide 2% / Tretinoin 0.025%
TRETIN-X Gel 0.01%
Tri-luma
TRETIN-X Cream 0.1%
Minoxidil 7% / Progesterone 0.1% / Tretinoin 0.025%
Hydroquinone 4% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.025%
Hydroquinone 4% / Tretinoin 0.025%
Niacinamide 2% / Spironolactone 5% / Tretinoin 0.025%
Vitamin A Acid 0.01% Cream
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.1%
141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Hydroquinone 5% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%
Solagé
011021 Niacinamide 4% / Tretinoin 0.05%
Dermawerx Zmt Pak
Refissa
Stievamycin Regular
Imiquimod 5% / Tretinoin 0.025%
Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Retin-A
011013 Niacinamide 4% / Tretinoin 0.025%
011218 Niacinamide 2% / Spironolactone 5% / Tretinoin 0.025%
141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%
Tretinoin (Emollient)
Tretinoin Gel Microsphere
Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%
Avita
Vitamin A Acid 0.025% Cream
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.1%
Stieva-A Gel
Hydroquinone 6% /tretinoin 0.05%
Obagi
Vitinoin - Crm 0.05%
011020 Niacinamide 4% / Tretinoin 0.05%
Benzoyl Peroxide 5% / Clindamycin1% / Niacinamide 2% / Tretinoin 0.025%
Clindamycin 1% / Sodium Sulfacetamide Monohydrate 5% / Tretinoin 0.025%
Tretinoin Cream
Benzoyl Peroxide 2.5%, Clindamycin Phosphate 1%, Niacinamide 2% / Tretinoin 0.05%
Clindamycin Phosphate and Tretinion
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.05%
Tretinoin
Biacna Topical Gel
TretinX
Imiquimod 5% / Salicylic Acid 30% / Tretinoin 0.1%
TRETIN-X Cream 0.05%
Ascorbyl Palmitate 2% / Hyaluronic Acid Sodium Salt 0.2% / Niacinamide 5% / Tretinoin 0.025%
Tretin-X
Vitinoin - Crm 0.025%
Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05%
Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05%
OLIVIA QUIDO FIRM and FADE I
Rejuva-A
Hydroquinone 8% / Tretinoin 0.025%.
011220 Niacinamide 2% / Spironolactone 5% / Tretinoin 0.05%
Vitinoin Gel - 0.025%
Dexamethasone Sodium Phosphate 0.1% / Finasteride 0.1% / Minoxidil 5% / Tretinoin 0.025%
Tretinopak
Fluocinolone Acetonide 0.01% / Minoxidil 5% / Tretinoin 0.025%
Clindamycin 1% / Niacinamide 4% / Spironolactone 2% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.05%
Hydroquinone 8% / Tretinoin 0.025%
Dermapak Plus
OLIVIA QUIDO FIRM and FADE II
Stievamycin Mild
Vitamin A Acid 0.05% Cream
Niacinamide 4% / Tretinoin 0.1%
Hyaluronic Acid Sodium Salt 0.5% / Hydroquinone 4% / Tretinoin 0.05%
Renova
Minoxidil 5% / Progesterone 0.1% / Tretinoin 0.025%
011010 Niacinamide 4% / Tretinoin 0.025%
Veltin
TRETIN-X Cream 0.025%
Niacinamide 4% / Tretinoin 0.025%
Finasteride 0.1% / Minoxidil 7% / Tretinoin 0.025%
Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Tretinoin 0.05%
Solage
Dapsone 8.5% / Niacinamide 2% / Tretinoin 0.025%
Stievaa Gel 0.01%
Stievamycin Forte
Tretinoin Gel
Vitinoin - Crm 0.1%
141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.05%
Clindamycin 1% / Niacinamide 4% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.025%
Dr. Throwers Pbc No. 1
Retisol-A
Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05%
Clindamycin 1% / Niacinamide 4% / Tretinoin 0.05%
Minoxidil 7% / Tretinoin 0.025%
Dapsone 6% / Niacinamide 2% / Tretinoin 0.025%
Stieva-A Cream
Vesanoid
Ziana
Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%
Niacinamide 2% / Spironolactone 5% / Tretinoin 0.05%
Dr. Throwers Hydrotet
141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Tretin.x
Refissa Tretinoin (Emollient)
Stie Vaa Sol 0.05%
Cenovia
TRETIN-X Gel 0.025%
Altreno
Clindamycin Phosphate 1.2% and Tretinoin 0.025%
Niacinamide 4% / Tretinoin 0.05%
Stieva-A Solution
Atralin
Description
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Target gene| Gene | Function |
|---|
| RXRB | agonist | | RXRG | agonist | | RARG | agonist | | ALDH1A1 | Unknown | | GPRC5A | Unknown | | ALDH1A2 | Unknown | | RARRES1 | agonist | | RARA | Unknown | | RARB | Unknown | | LCN1 | Unknown | | OBP2A | Unknown | | RBP4 | Unknown | | PDK4 | Unknown | | RXRA | Unknown | | CYP26A1 | Unknown | | CYP26B1 | Unknown | | CYP26C1 | Unknown | | HPGDS | Unknown |
|
| PML |
PML-RARA |
FUS |
Acute Promyelocytic Leukemia |
Tretinoin |
RII |
1 |
|
Evidence region
CIVIC
Patient Criteria
A216V
Note
The mutation A216V in the B2 domain of PML in the PML-RARa fusion was seen in a patient with ATRA-resistant acute promyelocytic leukemia.
Gene name
PML
Full name
PML nuclear body scaffold
Gene type
protein-coding
Function
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Drug name
Tretinoin
DrugBank ID
DB00755
Synonyms
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid (ECL)
Acide retinoique
all trans Retinoic acid
all trans-Retinoic acid
all-(E)-Retinoic acid
all-trans-beta-Retinoic acid
all-trans-Retinoic acid
all-trans-Tretinoin
all-trans-Vitamin A acid
all-trans-Vitamin A1 acid
ATRA
beta-Retinoic acid
Retinoic acid
Retionic acid
trans-Retinoic acid
Tretin M
Tretinoin
Tretinoina
Trétinoïne
Tretinoinum
Vitamin A acid
Brand
Hydroquinone 6% / Tretinoin 0.05% / Triamcinolone 0.025%
Retin-A MICRO
Vitamin A Acid
Benzoyl Peroxide 2.5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.025%
Clindamycin Phosphate and Tretinoin
Vitamin A Acid 0.1% Cream
Desoximetasone 0.05% / Hydroquinone 6% / Tretinoin 0.05%
Benzoyl Peroxide 5% / Niacinamide 2% / Tretinoin 0.025%
TRETIN-X Gel 0.01%
Tri-luma
TRETIN-X Cream 0.1%
Minoxidil 7% / Progesterone 0.1% / Tretinoin 0.025%
Hydroquinone 4% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.025%
Hydroquinone 4% / Tretinoin 0.025%
Niacinamide 2% / Spironolactone 5% / Tretinoin 0.025%
Vitamin A Acid 0.01% Cream
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.1%
141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Hydroquinone 5% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%
Solagé
011021 Niacinamide 4% / Tretinoin 0.05%
Dermawerx Zmt Pak
Refissa
Stievamycin Regular
Imiquimod 5% / Tretinoin 0.025%
Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Retin-A
011013 Niacinamide 4% / Tretinoin 0.025%
011218 Niacinamide 2% / Spironolactone 5% / Tretinoin 0.025%
141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%
Tretinoin (Emollient)
Tretinoin Gel Microsphere
Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%
Avita
Vitamin A Acid 0.025% Cream
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.1%
Stieva-A Gel
Hydroquinone 6% /tretinoin 0.05%
Obagi
Vitinoin - Crm 0.05%
011020 Niacinamide 4% / Tretinoin 0.05%
Benzoyl Peroxide 5% / Clindamycin1% / Niacinamide 2% / Tretinoin 0.025%
Clindamycin 1% / Sodium Sulfacetamide Monohydrate 5% / Tretinoin 0.025%
Tretinoin Cream
Benzoyl Peroxide 2.5%, Clindamycin Phosphate 1%, Niacinamide 2% / Tretinoin 0.05%
Clindamycin Phosphate and Tretinion
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.05%
Tretinoin
Biacna Topical Gel
TretinX
Imiquimod 5% / Salicylic Acid 30% / Tretinoin 0.1%
TRETIN-X Cream 0.05%
Ascorbyl Palmitate 2% / Hyaluronic Acid Sodium Salt 0.2% / Niacinamide 5% / Tretinoin 0.025%
Tretin-X
Vitinoin - Crm 0.025%
Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05%
Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05%
OLIVIA QUIDO FIRM and FADE I
Rejuva-A
Hydroquinone 8% / Tretinoin 0.025%.
011220 Niacinamide 2% / Spironolactone 5% / Tretinoin 0.05%
Vitinoin Gel - 0.025%
Dexamethasone Sodium Phosphate 0.1% / Finasteride 0.1% / Minoxidil 5% / Tretinoin 0.025%
Tretinopak
Fluocinolone Acetonide 0.01% / Minoxidil 5% / Tretinoin 0.025%
Clindamycin 1% / Niacinamide 4% / Spironolactone 2% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.05%
Hydroquinone 8% / Tretinoin 0.025%
Dermapak Plus
OLIVIA QUIDO FIRM and FADE II
Stievamycin Mild
Vitamin A Acid 0.05% Cream
Niacinamide 4% / Tretinoin 0.1%
Hyaluronic Acid Sodium Salt 0.5% / Hydroquinone 4% / Tretinoin 0.05%
Renova
Minoxidil 5% / Progesterone 0.1% / Tretinoin 0.025%
011010 Niacinamide 4% / Tretinoin 0.025%
Veltin
TRETIN-X Cream 0.025%
Niacinamide 4% / Tretinoin 0.025%
Finasteride 0.1% / Minoxidil 7% / Tretinoin 0.025%
Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Tretinoin 0.05%
Solage
Dapsone 8.5% / Niacinamide 2% / Tretinoin 0.025%
Stievaa Gel 0.01%
Stievamycin Forte
Tretinoin Gel
Vitinoin - Crm 0.1%
141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.05%
Clindamycin 1% / Niacinamide 4% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.025%
Dr. Throwers Pbc No. 1
Retisol-A
Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05%
Clindamycin 1% / Niacinamide 4% / Tretinoin 0.05%
Minoxidil 7% / Tretinoin 0.025%
Dapsone 6% / Niacinamide 2% / Tretinoin 0.025%
Stieva-A Cream
Vesanoid
Ziana
Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%
Niacinamide 2% / Spironolactone 5% / Tretinoin 0.05%
Dr. Throwers Hydrotet
141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Tretin.x
Refissa Tretinoin (Emollient)
Stie Vaa Sol 0.05%
Cenovia
TRETIN-X Gel 0.025%
Altreno
Clindamycin Phosphate 1.2% and Tretinoin 0.025%
Niacinamide 4% / Tretinoin 0.05%
Stieva-A Solution
Atralin
Description
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Target gene| Gene | Function |
|---|
| RXRB | agonist | | RXRG | agonist | | RARG | agonist | | ALDH1A1 | Unknown | | GPRC5A | Unknown | | ALDH1A2 | Unknown | | RARRES1 | agonist | | RARA | Unknown | | RARB | Unknown | | LCN1 | Unknown | | OBP2A | Unknown | | RBP4 | Unknown | | PDK4 | Unknown | | RXRA | Unknown | | CYP26A1 | Unknown | | CYP26B1 | Unknown | | CYP26C1 | Unknown | | HPGDS | Unknown |
|
| PML |
PML-RARA |
FUS |
Acute Promyelocytic Leukemia |
Tretinoin |
RII |
1 |
|
Evidence region
CIVIC
Patient Criteria
L218P
Note
The PML L218P mutation in the PML-RARa fusion was observed in a patient with previously ATRA-treated, relapsed acute promyelocytic leukemia refractory to arsenic trioxide.
Gene name
PML
Full name
PML nuclear body scaffold
Gene type
protein-coding
Function
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Drug name
Tretinoin
DrugBank ID
DB00755
Synonyms
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid (ECL)
Acide retinoique
all trans Retinoic acid
all trans-Retinoic acid
all-(E)-Retinoic acid
all-trans-beta-Retinoic acid
all-trans-Retinoic acid
all-trans-Tretinoin
all-trans-Vitamin A acid
all-trans-Vitamin A1 acid
ATRA
beta-Retinoic acid
Retinoic acid
Retionic acid
trans-Retinoic acid
Tretin M
Tretinoin
Tretinoina
Trétinoïne
Tretinoinum
Vitamin A acid
Brand
Hydroquinone 6% / Tretinoin 0.05% / Triamcinolone 0.025%
Retin-A MICRO
Vitamin A Acid
Benzoyl Peroxide 2.5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.025%
Clindamycin Phosphate and Tretinoin
Vitamin A Acid 0.1% Cream
Desoximetasone 0.05% / Hydroquinone 6% / Tretinoin 0.05%
Benzoyl Peroxide 5% / Niacinamide 2% / Tretinoin 0.025%
TRETIN-X Gel 0.01%
Tri-luma
TRETIN-X Cream 0.1%
Minoxidil 7% / Progesterone 0.1% / Tretinoin 0.025%
Hydroquinone 4% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.025%
Hydroquinone 4% / Tretinoin 0.025%
Niacinamide 2% / Spironolactone 5% / Tretinoin 0.025%
Vitamin A Acid 0.01% Cream
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.1%
141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Hydroquinone 5% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%
Solagé
011021 Niacinamide 4% / Tretinoin 0.05%
Dermawerx Zmt Pak
Refissa
Stievamycin Regular
Imiquimod 5% / Tretinoin 0.025%
Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Retin-A
011013 Niacinamide 4% / Tretinoin 0.025%
011218 Niacinamide 2% / Spironolactone 5% / Tretinoin 0.025%
141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%
Tretinoin (Emollient)
Tretinoin Gel Microsphere
Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%
Avita
Vitamin A Acid 0.025% Cream
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.1%
Stieva-A Gel
Hydroquinone 6% /tretinoin 0.05%
Obagi
Vitinoin - Crm 0.05%
011020 Niacinamide 4% / Tretinoin 0.05%
Benzoyl Peroxide 5% / Clindamycin1% / Niacinamide 2% / Tretinoin 0.025%
Clindamycin 1% / Sodium Sulfacetamide Monohydrate 5% / Tretinoin 0.025%
Tretinoin Cream
Benzoyl Peroxide 2.5%, Clindamycin Phosphate 1%, Niacinamide 2% / Tretinoin 0.05%
Clindamycin Phosphate and Tretinion
Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% / Tretinoin 0.05%
Tretinoin
Biacna Topical Gel
TretinX
Imiquimod 5% / Salicylic Acid 30% / Tretinoin 0.1%
TRETIN-X Cream 0.05%
Ascorbyl Palmitate 2% / Hyaluronic Acid Sodium Salt 0.2% / Niacinamide 5% / Tretinoin 0.025%
Tretin-X
Vitinoin - Crm 0.025%
Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05%
Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05%
OLIVIA QUIDO FIRM and FADE I
Rejuva-A
Hydroquinone 8% / Tretinoin 0.025%.
011220 Niacinamide 2% / Spironolactone 5% / Tretinoin 0.05%
Vitinoin Gel - 0.025%
Dexamethasone Sodium Phosphate 0.1% / Finasteride 0.1% / Minoxidil 5% / Tretinoin 0.025%
Tretinopak
Fluocinolone Acetonide 0.01% / Minoxidil 5% / Tretinoin 0.025%
Clindamycin 1% / Niacinamide 4% / Spironolactone 2% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.05%
Hydroquinone 8% / Tretinoin 0.025%
Dermapak Plus
OLIVIA QUIDO FIRM and FADE II
Stievamycin Mild
Vitamin A Acid 0.05% Cream
Niacinamide 4% / Tretinoin 0.1%
Hyaluronic Acid Sodium Salt 0.5% / Hydroquinone 4% / Tretinoin 0.05%
Renova
Minoxidil 5% / Progesterone 0.1% / Tretinoin 0.025%
011010 Niacinamide 4% / Tretinoin 0.025%
Veltin
TRETIN-X Cream 0.025%
Niacinamide 4% / Tretinoin 0.025%
Finasteride 0.1% / Minoxidil 7% / Tretinoin 0.025%
Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Tretinoin 0.05%
Solage
Dapsone 8.5% / Niacinamide 2% / Tretinoin 0.025%
Stievaa Gel 0.01%
Stievamycin Forte
Tretinoin Gel
Vitinoin - Crm 0.1%
141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.05%
Clindamycin 1% / Niacinamide 4% / Tretinoin 0.025%
Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.025%
Dr. Throwers Pbc No. 1
Retisol-A
Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05%
Clindamycin 1% / Niacinamide 4% / Tretinoin 0.05%
Minoxidil 7% / Tretinoin 0.025%
Dapsone 6% / Niacinamide 2% / Tretinoin 0.025%
Stieva-A Cream
Vesanoid
Ziana
Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%
Niacinamide 2% / Spironolactone 5% / Tretinoin 0.05%
Dr. Throwers Hydrotet
141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
Tretin.x
Refissa Tretinoin (Emollient)
Stie Vaa Sol 0.05%
Cenovia
TRETIN-X Gel 0.025%
Altreno
Clindamycin Phosphate 1.2% and Tretinoin 0.025%
Niacinamide 4% / Tretinoin 0.05%
Stieva-A Solution
Atralin
Description
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Target gene| Gene | Function |
|---|
| RXRB | agonist | | RXRG | agonist | | RARG | agonist | | ALDH1A1 | Unknown | | GPRC5A | Unknown | | ALDH1A2 | Unknown | | RARRES1 | agonist | | RARA | Unknown | | RARB | Unknown | | LCN1 | Unknown | | OBP2A | Unknown | | RBP4 | Unknown | | PDK4 | Unknown | | RXRA | Unknown | | CYP26A1 | Unknown | | CYP26B1 | Unknown | | CYP26C1 | Unknown | | HPGDS | Unknown |
|
| PML |
PML-RARA |
FUS |
Acute Promyelocytic Leukemia |
Arsenic trioxide |
I |
1 |
|
Evidence region
MyCancerGenome
Patient Criteria
-
Note
-
Gene name
PML
Full name
PML nuclear body scaffold
Gene type
protein-coding
Function
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Drug name
Arsenic trioxide
DrugBank ID
DB01169
Synonyms
Acide Arsenieux
Anhydride Arsenieux
Arsenic Blanc
Arsenic oxide
Arsenic trioxide
Arsenic(III) oxide
arsénico trióxido
Arsenigen Saure
Arsenolite
Arsenous oxide
Arsenous oxide anhydride
Diarsenic oxide
Diarsenic trioxide
White arsenic
Brand
Arsenic trioxide
Arsenic Trioxide Accord
Arsenic Trioxide for Injection
Arsenic Trioxide Mylan Infusion
Teva-arsenic Trioxide for Injection
Arsenic Trioxide Mylan
Arsenic Trioxide
Trisenox
Arsenic Trioxide Solution for Injection
Arsenic Trioxide Medac
Description
Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.
Target gene| Gene | Function |
|---|
| IKBKB | inducer | | TXNRD1 | inhibitor | | JUN | inducer | | CCND1 | antagonist | | MAPK3 | inducer | | MAPK1 | inducer | | AKT1 | inducer | | CDKN1A | Unknown | | HDAC1 | Unknown | | PML | Unknown |
|
| PML |
PML-RARA |
FUS |
Acute Promyelocytic Leukemia |
Arsenic trioxide |
I |
1 |
|
Evidence region
MyCancerGenome
Patient Criteria
Note
-
Gene name
PML
Full name
PML nuclear body scaffold
Gene type
protein-coding
Function
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Drug name
Arsenic trioxide
DrugBank ID
DB01169
Synonyms
Acide Arsenieux
Anhydride Arsenieux
Arsenic Blanc
Arsenic oxide
Arsenic trioxide
Arsenic(III) oxide
arsénico trióxido
Arsenigen Saure
Arsenolite
Arsenous oxide
Arsenous oxide anhydride
Diarsenic oxide
Diarsenic trioxide
White arsenic
Brand
Arsenic trioxide
Arsenic Trioxide Accord
Arsenic Trioxide for Injection
Arsenic Trioxide Mylan Infusion
Teva-arsenic Trioxide for Injection
Arsenic Trioxide Mylan
Arsenic Trioxide
Trisenox
Arsenic Trioxide Solution for Injection
Arsenic Trioxide Medac
Description
Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.
Target gene| Gene | Function |
|---|
| IKBKB | inducer | | TXNRD1 | inhibitor | | JUN | inducer | | CCND1 | antagonist | | MAPK3 | inducer | | MAPK1 | inducer | | AKT1 | inducer | | CDKN1A | Unknown | | HDAC1 | Unknown | | PML | Unknown |
|
| RARA |
RARA-PML |
FUS |
Acute Promyelocytic Leukemia |
Arsenic trioxide |
I |
1 |
|
Evidence region
MyCancerGenome
Patient Criteria
-
Note
-
Gene name
RARA
Full name
retinoic acid receptor alpha
Gene type
protein-coding
Function
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
Drug name
Arsenic trioxide
DrugBank ID
DB01169
Synonyms
Acide Arsenieux
Anhydride Arsenieux
Arsenic Blanc
Arsenic oxide
Arsenic trioxide
Arsenic(III) oxide
arsénico trióxido
Arsenigen Saure
Arsenolite
Arsenous oxide
Arsenous oxide anhydride
Diarsenic oxide
Diarsenic trioxide
White arsenic
Brand
Arsenic trioxide
Arsenic Trioxide Accord
Arsenic Trioxide for Injection
Arsenic Trioxide Mylan Infusion
Teva-arsenic Trioxide for Injection
Arsenic Trioxide Mylan
Arsenic Trioxide
Trisenox
Arsenic Trioxide Solution for Injection
Arsenic Trioxide Medac
Description
Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.
Target gene| Gene | Function |
|---|
| IKBKB | inducer | | TXNRD1 | inhibitor | | JUN | inducer | | CCND1 | antagonist | | MAPK3 | inducer | | MAPK1 | inducer | | AKT1 | inducer | | CDKN1A | Unknown | | HDAC1 | Unknown | | PML | Unknown |
|
